Brain Cell is the brain child of Ryan Gibson for the U.K.-based development team DESQ, an organization devoted to the development of Web-based and digital learning projects. In a recent attempt to contribute to casual gaming, DESQ released Brain Cell in the hopes of enhancing your typical room escape game and taking it to the next level. In many ways, it succeeds; featuring a gorgeous (yet bandwidth-intensive) take on the usual point-and-click, room escape genre.

Deep Chalk, from game author Zack Livestone, is a charming and interactive point-and-click, in which you clear the way for a powerful crystal to escape its confines, presumably to reach a higher plane of crystallinity. Its interactive Samorostian landscapes are augmented wonderfully by ethereal music clips to produce a deep, if slightly dry, experience.

A brand new point-and-click adventure from the master, Mateusz Skutnik, and his Pastel Games crew. All the pieces are in place for yet another fantastic escape game experience, as well as an entirely new series of games not to be missed.

The Final Spell is a charming and fun point-and-click game of the escape-the-room variety. Its most redeeming quality is its sense of humor, provided mainly by the many pamphlets and books scattered around the room, and sheer cuteness; an endearing amateurish sensibility is combined with just enough substance to leave you grinning.

The PonPon House is an adorable point-and-click adventure from the Japanese game design group, Orange Biscuit. Short and sweet, this one isn't likely to take up much time or energy. However, with the soothing background sounds of a gentle sea combined with elegant scenery, the game is more like a journey through a landscape painting rather than an adventure.

For those who enjoyed the previously reviewed Ambivalence, there's a brand new game, Confined, just released today from the same Japanese developer, FonGeBooN. This appears to be a fairly standard point-and-click room escape game until you dig a little deeper. From what I can tell so far, pixel hunting is minimal (though present), instead the focus is on puzzle solving, which is always a plus when it comes to games like this.

Trapped Part 2: The Dark is the middle installment in a trilogy of puzzle adventure games distinguished by a literary flavor and an unusual perspective. This series has a lot more in common with the old Infocom text adventures than it does with modern point-and-click games. Rather than relying on abstract puzzles and thorough visual investigation, the Trapped games plop you in a mundane environment, lavish you with a huge inventory, and then ask you to be extremely clever.

Room escape game lovers are in for a treat as Taro Ito weighs-in with his rendition of the point-and-click art form popularized by such games as MOTAS and the Viridian Room. Escape game is a simple and effective game of its genre with all the usual mechanics, but without the pixel hunting that often accompanies games like this.

From GUMP, the creator of Rental House comes another well-produced point-and-click, room escape game. Guest House puts you in a similar situation as most games of its type, and yet once you begin to move about the room and examine the various items and objects that await your puzzle-solving skills you will see that this is no ordinary room escape game.

Instead of walking around a room turning over objects and poking your nose in every corner, in Ambivalence your goal is to unlock a very secure-looking door that sits right in front of you. The fun twist is that you play from both sides of the door, switching views with the click of a button. Items you find on one side do not transfer to the other, creating a unique collaboration-style atmosphere where you are your own partner.

DayMare Town is a strange and oddly deserted town that gives the unsettling feeling that eyes are peering from around corners. It is drab and dreary, not a very pleasant place to be. But now you're stuck, and you'll do anything you can to leave.

Just when you thought you had seen the last of the Submachines for a while, Mateusz Skutnik comes around full circle and delivers another installment in one of the best point-and-click room escape game series on the Web. Submachine: Future Loop Foundation features music from a band of the same name (Future Loop Foundation) and it sets the mood very nicely for another enjoyable adventure.

Loose the Moose is the latest point-and-click, escape-the-room game from Bart Bonte. As with most other games like it, the premise is a simple one: you're in a room, you need to get out. You will have to be observant and think logically to solve puzzles that lead you to your escape.

Enter the Rental House and note the viridian green walls. This Japanese-made adventure offers a quality game play experience packed with puzzles that will force you to think logically. It is a straight forward game of its genre with only a couple of minor pixel hunts involved. Easy enough to complete on ones own, and yet challenging to give you about an hour's worth of fun.

On of Eyezmaze continues to impress and amaze us with his game development skills, and Dwarf Complete is no exception. Perhaps his most ambitious project to date, the game was commissioned for the online RPG, Lineage II, and it even features dwarves from that game. Dwarf Complete is an amazingly good adventure puzzle game with quality, presentation and gameplay that all helped push this title to the top of the Best of 2007.

O Quarto is a great looking point-and-click game made by Andres Calil of Me Pixa. Once again you are trapped in a room and must search the area for items to help you escape. The art style of this game is superb and reminds me of an interactive oil painting. The game is also quite mysterious and offers some wonderfully perplexing mysteries that must be solved in order to escape.

Out 2: Out of File is the sequel to the room escape game Out File #01 by Isomura Kai of Tonakai Interactive. The story picks up after escaping the room in the first game and walking through a long winding cave. Now you find yourself in an underground complex filled with computers and machinery with no way to make it to the surface.

Dona Room 2 is the second room escape game from Japanese flash designer Noaki Nakashima. The game is every bit as quirky and amusing as the original Dona Room and offers more great point-and-click gameplay. The entire game takes place in your kitchen where a note from your mother says you must find a snack before you can leave. Unfortunately the potato chips and cake are locked away, so you must find items and solve puzzles in order to get to them. The game has a little Japanese text but is completely playable without knowledge of the language.

A flash design project by Phillip Reagan of Texas, USA, Thief weaves a cryptic atmosphere with captivating puzzles to pull you into a story you didn't even realize you were participating in. Thief is a well-deserving runner-up in our very first Casual Gameplay Design Competition.

One-Off is the latest escape-the-room creation by the Gotmail team. This time your task is to get a beautiful blue motorcycle out from the garage where it's kept. The motorcycle is locked, and so is the door to the garage. In order to open them, you'll have to search the garage for gadgets and clues and combine those with the environment at the appropiate places.

Developer Code is a series of six (6) point-and-click games of the escape-the-room variety, brought to us by IBM in China. The gameplay is the usual for this kind of game: For a reason unknown to you, you find yourself in a locked room with no apparent way out.

Bonte Room 2 is the sequel to Bart Bonte's first room escape game we featured back in December. The game shares a lot with its predecessor, including simplistic art style, room layout, and a strange animal that's integral to solving the game's puzzles.

The Privacy is another Flash point-and-click adventure from the stellar Gotmail team that gave us The Bar, Il Destino, The Salon and others. The game is set in a high-tech, big-brother world where even the watchers are watched and elaborate security systems are commonplace.

Il Destino R is a revamped version of the original Il Destino point-and-click room escape game. It isn't a sequel, but the puzzles are different, items have moved around, new items make an appearance, and there are a few extra nooks and crannies to uncover. The layout and visuals are identical in both games, but R offers more challenge and features a completely different car on center stage.

Bart Bonte sends word of his brand new point-and-click adventure, The Bonte Room. And besides being a rather typical escape-the-room type of game, it is an exceptional effort. The stylized graphics are simple yet pleasing, and the puzzles are all quite logical.

Created by Toshimitsu Takagi, the mastermind behind several of the very best escape-the-room type games available on the Web today, the White Chamber follows the same compelling point-and-click formula that made its predecessor, Viridian Room, so successful and enjoyable to play. Not to be missed.

The Dark Complex builds on the brilliant puzzle work of the first game, The Dark Room, by creating an entire complex of rooms, each with its own unique puzzle inside. This is a game that will keep you busy and mesmerized for hours. Be sure to bring a paper and pencil with you, you'll need them to find your way out of this dark, complex game.

My Diamond Baby is a single-room point-and-click escape game. You start off as someone on a motorcycle on his way to give an engagement ring to his girlfriend. On his way he is involved in a motorcycle accident. When he regains consciousness he finds himself locked in a room without the engagement ring. This is by far the most challenging point-and-click game I have ever played. Imagine Crimson Room, Viridian Room, and the Blue Chamber all rolled up into one.

Dr. Stanley's House was created by James Li and is a point-and-click adventure game. It has a mysterious plot with some twists and turns that is very creepy at times. The lush colored graphics provide a striking contrast to the moody atmospheric soundtrack, with several cut scenes that develop the story as you play.

In Travelogue, another Flash escape-the-room game, you find yourself in a hotel room far from where you'd like to be. Use what resources are available to navigate around the area and locate items and clues that you can use to help you escape. Most of the puzzles are logical in design,...

Featuring original and commercial-quality graphics, animation and sound, Mink of 3wish.com has created these cute, point-and-click, cartoon puzzles in Flash. Each episode is rather short in length—just right for some lunchtime fun or a coffee break—and all of them contain humorous and inventive situations and clever puzzles to solve.

The grandaddy of all escape-the-room games, Jan Albartus' Mystery of Time and Space dates way back to 2001 which, in terms of casual Web games, is almost the beginning of time. In MOTAS, you don't get to escape from just one room, oh no. There are now 20 rooms to escape from! Limber up those point-and-click fingers, you're about to embark on an epic classic.

You don't know where you are, and you don't know what you're doing there. You just know you have to get out. Such is the scenario that The Doors drops you into when this excellent point-and-click adventure game begins. Truly one of the best of its kind.

The Dark Room is an absolutely brilliant Flash puzzle game that is as gorgeous as it is enjoyable. Using only the mouse, point, click and solve the mystery of the dark room in this amazing and remarkable hi-tech themed puzzle game. Created by Jonathan May of Woolythinking.

You have been sent to detention with a couple of your friends, and locked in a room in the school by the evil principal seeking revenge. The only way out is to use your ingenuity and resources around you, along with the help of your friends, to Escape from Detention. Use your mouse to click on any of the three students, Serin, Geo or Bravo, then click to move around each room and pick up items. Inventory items may be combined to solve puzzles, and even shared between students.

Viridian Room is a place you wish to escape from, but have you the soul to withstand the challenge? Muha-ha-ha-ha-ha! This point-and-click puzzle game was one of the very first escape-the-room type Flash Web games. Nicely done with eerie sound effects.