Roguelike, The Legend of Zelda, a dual stick shooter, and the twisted mind of Edmund McMillen, part of the team behind Super Meat Boy. Put them all together and you've got The Binding of Isaac, a game that is as unhinged as it is entertaining, as good-looking as it is, well, disgusting. Even still, it's the kind of game you'll play through again and again, just to collect every item and explore every corner of the game's randomly-generated world.

Meat Boy is back in his first commercial release! When the evil Dr Fetus absconds with Meat Boy's beloved Bandage Girl, he leaps to the rescue across more than 300 levels, braving saw blades, syringes, mutant blood clots, toxic waste, and much, much more. As twisted as it is charming and devious, Super Meat Boy is a fantastic and fantastically hard platformer that is tremendous fun.

This platform puzzle game from Edmund McMillen brings to the platformer table multi-dimensional planes. Press the [A] key to switch planes and alter what is visible on the screen. Sometimes you can see the other planes while you are occupying the current one, but you can't see what overlaps between planes. This creates an interesting dynamic that involves a lot of guessing with your jumps, especially when movable blocks make their appearance.

Help guide Spewer, an adorable pink blob, through a series of diabolical tests put forth by a watchful scientist in this physics-based platformer. It's a journey of adventure, excitement, and child-like wonder. Also, vomit.

Grey Matter is an anti-shooter, which means that you can't actually shoot. You are the bullet, and you attack by directly colliding with the exposed brain-meats of your enemies. It looks great and sounds even better. The gameplay has all the depth of a modern professional shoot-'em-up, thanks to the combo system. Grey-Matter is perfectly playable without using the Trinity Attacks, but if you do employ them, it becomes almost like a hyperactive, twitchy puzzle game.

Meat Boy is a platform game that dares to ask the question "What if the main character from Knytt or N was made of bits of sticky, gooey raw meat?" And even though you never wanted to listen to the sound of meat slapping against solid blocks over and over again, when you're playing Meat Boy, you probably won't mind.

Aether is a gloriously imaginative and atmospheric puzzle adventure game in which you swing through the stars to reach several different planets, each with a unique puzzle to solve. The designers have made a truly compelling experience, and it's a fantastic artistic endeavor. You can also just spend some time flying through space or the clouds, the music and movement are so relaxing.

From the deranged minds of Edmund McMillen and Florian Himsl (Komix) comes the most important game about vagrant hallucinations ever made: Twin Hobo Rocket. Control a rocket to which are tied twin hobos as they hustle change from floating balloons and irritated aliens. Topping off the insanity is a crucial song by Kadaa and hilarious voice-over dialogue between the two bums.

Coil is a game unlike any other; it may confuse you, it may offend you, or it might mystify and move you. Coil is a game about discovery. It is also a series of mini-games involving the gestation of what appears to be an alien fetus, from initial insemination through adulthood when a murky twilight leaves its fate in question and the cycle starts anew.

Tri-achnid is a new action/adventure platformer in which you play as a creature of an endangered species of exopod on the verge of extinction. Your goal is to find a safe place for your brothers and sisters, who are tucked away in a portable cocoon, by moving throughout each level using a unique click-drag gameplay mechanic.