Starseed Pilgrim is a very, very unusual game. Created by droqen, author of Probability 0, it's best described as an abstract puzzle game with some light musical elements and a touch of sandbox-style gameplay. That doesn't do the experience justice, though, as its real value comes from the sense of exploration and wonder you'll get trying to figure out which seeds grow which blocks and what exactly you're trying to accomplish in this bleak world.
Proteus is a exploration-based piece of interactive art by Ed Key and David Kanaga. In it, players take a walk through an abstract procedurally-developed island. While Proteus is probably not going to challenge the conception some have of art games as low-rez inaction-fests, that niche of gamers who'd be interested in a chill 45-minute retro vacation will find it a place worth hearing, and a song worth exploring.